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Biomaterials Day, Rice University
 

Abstracts


 Undergraduate Abstracts

1. Architectural Gradient Scaffolds for Subchondral Restoration
Diana Castillo1, Sergio Montelongo1, Teja Guda1, Joo Ong1
The University of TX at San Antonio, 1Department of Biomedical Engineering

2. Select Choroidal Endothelial Cell Functions under Elevated Pressure and High Glucose Concentrations
K. A. Hamalainen, M. E. Wechsler, R. Bizios and M. A. Reilly
Department of Biomedical Engineering, The University of TX at San Antonio, San Antonio, TX

3. Liquid Crystal Elastomers as Active Substrates for Dynamic Cell Culture
Aditya Agrawal1, Oluwatomiyin Adetiba2, Hojin Kim1, Huiying Chen2, Jeffrey G. Jacot2,3, and Rafael Verduzco1
1Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX; 2Department of Bioengineering, Rice University, Houston, TX; 3Division of Congenital Heart Surgery, TX Children’s Hospital, Congenital Heart Surgery Services, Houston, TX

4. Characteristics and Properties of Silk Scaffolds
Joseph J. Pearson1, Solaleh Miar1, Teja Guda1,PhD, and Joo L. Ong1, PhD
1Department of Biomedical Engineering, The University of TX at San Antonio, San Antonio, TX

5. Achieving Tunable Degradation of PolyHIPE Bone Grafts
Hannah Pearce1, Jenny Robinson1, Tyler Touchet1, Madison McEnery1, and E. Cosgriff-Hernandez1
1Biomedical Engineering, TX A&M University, College Station, TX

6. Electrochemically-Pre-adsorbed Collagen Promotes Adult Human Mesenchymal Stem Cell Adhesion on Optically Transparent Nanostructured Carbon Substrates
M. E. Wechsler1, T. E. Benavidez2, M. M. F. Farrer1, R. Bizios1, and C. D. Garcia2
Departments of 1Biomedical Engineering and 2Chemistry, The University of TX at San Antonio, San Antonio, TX

7. Sequential Click Reactions for the Polymerization and Functionalization of Poly(ethylene glycol) Based Hydrogel Microparticles
Ramanathan Yegappan1, Faraz Jivan1, Akhilesh K. Gaharwar1,2, Daniel L. Alge1,2
1Department of Biomedical Engineering, TX A&M University, College Station, TX; 2Department of Materials Science and Engineering, TX A&M University, College Station, TX

8. Promoting Vascularized Bone Tissue Regeneration on Composite Scaffolds Using Spatial and Temporal Control
Rebekah Rodriguez1; Laura Gaviria1; Joo Ong, PhD1; Teja Guda, PhD1
1Department of Biomedical Engineering, University of Texas at San Antonio

Graduate Abstracts

9. Dynamic increase in matrix stiffness promotes invasive tumor phenotype in vivo
Shane C. Allen1, Nancy D. Ebelt2, Ryan S. Stowers3, Carla Van Den Berg4, and Laura J. Suggs1
1Department of Biomedical Engineering, The University of TX at Austin; 2Institute of Cellular & Molecular Biology, College of Pharmacy, The University of TX at Austin, 3Department of Mechanical Engineering, Stanford University; 4College of Pharmacy, The University of TX at Austin

10. A Versatile, Automated, Optical Cell Counting Approach for the Quantification of Multiple Adherent Cell Types
Vishwaratn Asthana1, Adam Ferguson1, Anantratn Asthana2, Yuqi Tang1, Pallavi Bugga1, Allen Chen1, Rebekah Drezek1
1Rice University, Houston, TX; 2University of California, Berkeley, Berkeley, California

11. Mechanical Characterization and DNA Quantification of Porcine SIS-ECM Scaffolds
Oluwadamilola Ayanlakin1; Laura Gaviria1; Anson Ong1; Teja Guda1
1The University of TX at San Antonio, San Antonio, TX

12. Biodegradable DNA-Enabled Poly(ethylene glycol) Hydrogels Prepared by Copper-Free Click Chemistry
Karolyn Barker,1 Shiva K. Rastogi,1 William Brittain,1 Tania Betancourt1,2,*
1Department of Chemistry and Biochemistry, TX State University; 2Materials Science, Engineering, and Commercialization Program, TX State University

13. Conductive Polymer-Based Nanoparticles As Photothermal Therapy Agents: Synthesis and Characterization
Travis Cantu,1 Kyle Walsh,2 Sumeet Mishra,3 Joseph Tracy,3 Varun Pattani,4 James Tunnell,4 Jennifer Irvin,1,2 Tania Betancourt,1,2
1Materials Science, Engineering, and Commercialization Program, TX State University; 2Department of Chemistry and Biochemistry, TX State University; 3Department of Materials Science and Engineering, North Carolina State University; 4Department of Biomedical Engineering, The University of TX at Austin

14. Synthesis of Cobalt Crosslinked Albumin Nanoparticles and In Vitro Evaluation of Macropinocytic Uptake in Gastric Carcinoma Cells
Ronaldo J. Cavazos Jr., Clifford S. Morrison, Jana B. Lampe, Duong T. Nguyen, Alesha N. Harris, Brian K. McFarlin, and Robby A. Petros
University of North TX

15. Development of Chronic Wound Dressing Based on Collagen-Mimetic Proteins
Stacy Cereceres1, Tyler Touchet1, Mary Beth Browning2, Clayton Smith1, Jose Rivera2, Magnus Höök2, Canaan Whitfield-Cargile3, Brooke Russell2, and Elizabeth Cosgriff-Hernandez1
1Department of Biomedical Engineering, TX A&M University, College Station, TX; 2Institute for Bioscience and Technology, TX A&M Health Science Center, Houston, TX; 3Department of Large Animal Clinical Sciences, TX A&M University, College Station, TX

16. Synthesis and Characterization of Smart Molecularly Imprinted Polymers, Using Structural Analogue Templates, for the Capture and Detection of Biomolecules
John R. Clegg1,4, Heidi R. Culver1,4, Justin Zhong2, Afshan S. Irani1 and Nicholas A. Peppas1,2,3,4
1Department of Biomedical Engineering; 2McKetta Department of Chemical Engineering; 3College of Pharmacy; 4Institute for Biomaterials, Drug Delivery, and Regenerative Medicine, University of TX at Austin, Austin TX

17. Understanding the importance of backbone hydrogen bonding in small peptide selfassembly and the RGD-integrin interaction: consequences for engineering degradable cell-adhesive biomaterials
Kevin M. Eckes, Kiheon Baek, Laura J. Suggs
Department of Biomedical Engineering, The University of TX at Austin, Austin, TX

18. Gap Junction Liposomes for Direct Therapeutic Delivery to the Cytoplasm
Avinash Gadok, Jeanne Stachowiak
Department of Biomedical Engineering, The University of TX at Austin, Austin, TX

19. Human pediatric cardiac cells exhibited high viability in 3D culture and limited expression of SSEA-4 and Isl1
Yang Gao1, Jeffrey G. Jacot1,2
1Department of Bioengineering, Rice University, Houston, TX; 2Division of Congenital Heart Surgery, TX Children’s Hospital, Houston, TX

20. Single growth factor release from PLA-based microparticles for recruitment and differentiation of osteoprogenitor cells
Laura Gaviria; Teja Guda, PhD; Joo L. Ong, PhD
The University of TX at San Antonio

21. Healing osteochondral defects of the knee:  regenerative osteochondral plugs
Glidewell, H; Gacasan, E; Sehnert, R; Grunlan MA
Texas A&M University, Department of Biomedical Engineering, College Station, TX

22. Enhancing Bone Regeneration with Composite Microspheres that Reflect the Osteogenic Niche
Candice Haase1, Colin Dodson1, Chi-Heng Wu1, Allison Rice-Ficht, Ph.D.2,Carl Gregory, Ph.D.3, and Roland Kaunas, Ph.D.1
1Texas A&M University, College Station, TX; 2Texas A&M Health Science Center, College Station, TX; 3Texas A&M Health Science Center, Temple, TX

23. Opacification of shape memory polymer foams using tungsten nanoparticles for neurovascular embolic applications
Sayyeda M. Hasan1, Garrett Harmon1, Fang Zhou3, Jeffery E. Raymond2, Tiffany P. Gustafson2, Thomas S. Wilson4, Duncan J. Maitland1
1Texas A&M University Department of Biomedical Engineering, College Station, TX; 2Texas A&M University Laboratory for Synthetic-Biologic Interactions, Department of Chemistry, College Station, TX; 3University of Minnesota College of Science and Engineering, Minneapolis, MN; 4Lawrence Livermore National Laboratory, Livermore, CA

24. Optimizing Microcarrier Loading for Oral Durg Delivery Systems
Horava, S D1; Liou, J2; Peppas, N A1, 2, 3
1Department of Chemical Engineering; 2Department of Biomedical Engineering; 3College of Pharmacy, The University of TX at Austin, Austin, TX

25. Multi-Drug Core-Shell Nanoparticles for Targeted Lung Cancer Dual Therapy
Jyothi U. Menon1,2, Aneetta E. Kuriakose1,2, Roshni Iyer1,2, Elizabeth Hernandez2, Leah Gandee2, Shanrong Zhang2, Masaya Takahashi2, Zhang Zhang2, Debabrata Saha2, Kytai T. Nguyen1,2
1 University of TX at Arlington, Arlington, TX 76019; 2 The University of TX Southwestern Medical Center, Dallas, TX

26. Skeletal Fracture Risk Following Local Bone Injury
Suyash Karajgar1; Marcello Pilia2; Christopher Rathbone2; Teja Guda1
1University of TX at San Antonio, San Antonio, TX; 2US Army Institute of Surgical Research, Ft. Sam Houston, TX

27. Multi-functional Meshes to Prevent Intestinal Anastomotic Leakage and Surgical Adhesions
A. Kishan1, T. Touchet1, C. Whitfield2, N. Cohen2, E. Cosgriff-Hernandez1
1 Biomedical Engineering; 2 College of Veterinary Medicine, TX A&M University, College Station, TX 

28. Evaluation Of Polyelectrolyte Hydrogels Incorporating Poly(L-Lysine) as a Stimulant Of Chondrogenic Differentiation For Cartilage Tissue Engineering
Johnny Lam, Elisa Clark, Esther J. Lee, Eliza L.S. Fong, Steven Lu, and Antonios G. Mikos
Department of Bioengineering, Rice University, Houston, TX

29. Osteochondral tissue repair using a bilayered hydrogel composite delivering spatially-guided dual growth factors
Lu S1, Lam J1, Mikos AG1,*
1Department of Bioengineering, Rice University, Houston

30. Self-cleaning, Mechanically Robust Membranes for Implanted Glucose Biosensors
Means, A. K.1; Fei, R.2; Abraham, A. A.2; Coté, G. L.2; and Grunlan, M. A.1,2
Department of Materials Science & Engineering1, Department of Biomedical Engineering2, TX A&M University, College Station, TX

31. Hydroxyapatite-Carbon nanotube (HA-CNT) composite scaffolds for bone tissue engineering
Sergio Montelongo1, Alice Hsieh1, and T. Guda1, Anson Ong1
1Department of Biomedical Engineering, The University of TX at San Antonio

32. Self-Fitting Shape Memory Polymer Scaffolds for Bone Defect Repair
Lindsay N. Nail1, Dawei Zhang2, Keri M. Peterson1, Olivia J. George1, Jessica L. Reinhard1, Hanna R. Glidewell1, Melissa A. Grunlan1,2
Dept. of Biomedical Enginering1; Dept. of Materials Science and Engineering2; TX A&M University, College Station, TX

33. Synthesis and Applications of Antioxidant Carbon Nanomaterials
Lizanne G. Nilewski, William K. A. Sikkema, Dr. James M. Tour*
Department of Chemistry, Rice University

34. Nanoparticles for gene therapy: an alternative treatment for hindlimb ischemia
Linda Noukeu1,2, Subhash Banerjee2,3, Liping Tang1,2, Kytai T. Nguyen1,2
1Department of Bioengineering, University of TX at Arlington, Arlington, TX; 2Department of Biomedical Engineering, The University of TX Southwestern Medical Center, Dallas, TX; 3Division of Cardiology, VA North TX Health Care System at Dallas, Dallas, TX 

35. Polymeric Nanoparticle-Based Enzymatically Activatable Near-Infrared Nanoprobes for Optical Detection of Cancer
Tugba Ozel1, Sean White2, Elaine Nguyen2, Austin Moy2, Nicholas Brenes3, Bernard Choi2, and Tania Betancourt1, 3,4
1Materials Science, Engineering and Commercialization Program, TX State University, TX; 2Beckman Laser Institute and Department of Biomedical Engineering, University of California-Irvine, CA; 3InnoSense LLC, Torrance, CA; 4Department of Chemistry and Biochemistry, TX State University, TX

36. Thermo-responsive, multimodal imaging enabled nanoparticles towards cancer therapy
Nikhil Pandey1,2, Aniket S. Wadajkar1,2, Jyothi U. Menon1,2, Varsha Sundaresan1,2, Elizabeth Hernandez3, Jer-Tsong Hsieh3, Liping Tang1,2, Jiang Yang4, Kytai T. Nguyen1,2
1 Department of Bioengineering, University of TX at Arlington, Arlington, TX 76019; 2Department of Biomedical Engineering; 3Department of Urology, The University of TX Southwestern Medical Center, Dallas, TX, 75390; 4Bioengineering Department, The Pennsylvania State University, University Park, PA 16802

37. Microfiber Fabrication from Nanoparticle Polymeric  Solutions for Cellular Encapsulation
C.W. Peak1, J. Carrow1, A. Thakur1, A.K. Gaharwar1
1Texas A&M University, College Station, TX

38. Torsional Evaluation of Collagen Coated Hydroxyapatite with Varying rhBMP-2 Dosages in an In Vivo Critical Sized Rabbit Radius Model
Joseph J. Pearson1, Suyash Karajgar1, Stephanie Shiels2, Joseph Wenke2, Teja Guda1,PhD, and Joo L. Ong1, PhD
1The University of TX at San Antonio, San Antonio, TX; 2US Army Institute of Surgical Research, Ft. Sam Houston, TX

39. Surface Hydrolysis Mediated PEGylation of PNIPAAm Nanogels
Jonathan T. Peters1,4, Nicholas A. Peppas1,2,3,4
1Department of Chemical Engineering; 2Department of Biomedical Engineering; 3College of Pharmacy; 4Institute of Biomaterials, Drug Delivery, and Regenerative Medicine, The University of TX at Austin, Austin, TX

40. Development of Suturable and Bioactive Hydrogels to Promote Endothelialization of Vascular Grafts
A.D. Post, S. Cereceres, A. Kishan, M.B. Browning, B. Russell, J. Rivera, M. Höök, E. Cosgriff-Hernandez
Biomedical Engineering, TX A&M University, College Station, TX; Institute for Biotechnology, Houston, TX

41. Hyaluronan Hydrogels as Biomimetic Spongiosa Layer for Tissue Engineered Heart Valves
Dan Puperi1, Zoe Punske1, Ronan O’Connell2, Yan Wu3, Jennifer West3, Jane Grande-Allen1
1Rice University, Department of Bioengineering, Houston, TX; 2Glasgow University, Department of Biomedical Engineering, Glasgow, UK; 3Duke University, Department of Biomedical Engineering, Durham, NC

42. PEO-silane amphiphiles to prevent protein adsorption on silicone: Dependence on PEO-segment length and concentration
Marc A. Rufin,a Mikayla E. Barry,a Paige A. Adair,a Melissa L. Hawkins,a Jeffery E. Raymond,b and Melissa A. Grunlana,c
aDepartment of Biomedical Engineering; bDepartment of Chemistry; cDepartment of Materials Science and Engineering,
TX A&M University, College Station, TX

43. Effect of Flow Conditions in a 3D Tumor Model Generated Using a Flow Perfusion Bioreactor
Marco Santoro1,2, Salah-Eddine Lamhamedi-Cherradi2, Brian A. Menegaz2, Joseph A. Ludwig2 and Antonios G. Mikos1,3
1Department of Chemical and Biomolecular Engineering, Rice University, Houston, TX; 2Department of Sarcoma Medical Oncology, The University of TX MD Anderson Cancer Center, Houston, TX; 3Department of Bioengineering, Rice University, Houston, TX

44. Solid Freeform Fabrication of High Porosity Foams
Nick Sears, M.S., Dhruv Seshadri, Michael Whitely, and Elizabeth Cosgriff-Hernandez, Ph.D.
Department of Biomedical Engineering, TX A&M University, College Station, TX

45. Cure-On-Dispense Printing of High Porosity Foams using Redox Initiation
Dhruv Seshadri, Nick Sears, and Elizabeth Cosgriff-Hernandez
Department of Biomedical Engineering, TX A&M University, College Station, TX

46. Clindamycin-releasing Porous Poly(methylmethacrylate) space maintainers for Prevention of Mandibular Infection
Shah SR1, Tatara AM1, Lam J1, S. Lu1, G. N. Bennett1, van den Beucken JJJP2, Jansen JA2, Wong ME3, Mikos AG1
1Department of Bioengineering, Rice University, Houston, TX; 2Department of Biomaterials, Radboud University Medical Center, Nijmegen, The Netherlands; 3Department of Oral and Maxillofacial Surgery, University of TX Health Science Center at Houston, Houston, TX

47. Encapsulation of Polyanhydride Nanoadjuvants in Biodegradable Microgels for Oral Delivery
Lindsey Sharpe1, Olivia Mutaz-Haddadin2, Jeyvikram Thirumavalavan1, Yasmine Khairandish1 and Nicholas A. Peppas1,2,3
1Department of Biomedical Engineering; 2Department of Chemical Engineering; 3Division of Pharmaceutics, University of TX at Austin, Austin, TX-78712-1062

48. Synthesis and Characterization of Cationic Nanogels for Enhanced Cancer Therapy
David S. Spencer1, Bryan C. Luu1, Nicholas A. Peppas1-4
1McKetta Department of Chemical Engineering, The University of TX at Austin; 2Department of Biomedical Engineering, The University of TX at Austin; 3Institute for Biomaterials, Drug Delivery and Regenerative Medicine, The University of TX at Austin; 4College of Pharmacy, The University of TX at Austin, Austin, TX

49. Interpenetrating Collagen-Fibrin Hydrogels for Skeletal Muscle Regeneration
Sarah J. Stagg1; Beth E. Pollot1,2; Christopher R Rathbone2; Anson Ong1; Teja Guda1,2
1The University of TX at San Antonio, San Antonio, TX, 2US Army Institute of Surgical Research, Ft. Sam Houston, TX

50. Design and development of pH-responsive hydrogel systems for the oral delivery of therapeutic proteins
Stephanie Steichen1, Colleen O’Connor1, and Nicholas A. Peppas1,2,3
1Department of Biomedical Engineering; 2McKetta Department of Chemical Engineering; 3College of Pharmacy, The University of TX at Austin, Austin, TX

51. Elastomer/Gelatin Composite Membranes for Treatment of Cutaneous Mold Infection
Alexander M. Tatara1, Nathanial D. Albert2, Sarita R. Shah1, Dimitrios P. Kontoyiannis2, and Antonios G. Mikos1
1Department of Bioengineering, Rice University, Houston, TX; 2Department of Infectious Diseases, the University of TX MD Anderson Cancer Center, Houston, TX

52. Synthesis and Characterization of Biodegradable Polyurethane-ureas as Biomaterials for Soft Tissue Applications
Tyler Touchet, Alysha Kishan, Renee Calderon, and Elizabeth Cosgriff-Hernandez, PhD
Department of Biomedical Engineering, TX A&M University, College Station, TX

53. Reprogramming and Cardiac Differentiation of Amniotic Fluid Derived Stem Cells for the Repair of Congenital Heart Defects
Christopher J.M. Tsao1, Aaron J. Velasquez-Mao1, Jeffrey G. Jacot1,2
1Department of Bioengineering, Rice University; 2Congential Heart Surgery Service, TX Children’s Hospital

54. In Vitro and In Vivo Mineralization and Osteogenesis of InjectableStem Cell Laden Hydrogels
Vo, Tiffany N1, Roh, Terrence T1, Shah, Sarita R 1, Lu, Steven1, Lee, Esther J1, Tatara, Alexander M1, Mikos, Antonios G1
1Department of Bioengineering, Rice University, Houston, TX

55. Intravascular Canine Patent Ductus Arteriosus Closure Device
M.A. Wierzbicki1, J. Bryant1, M.W. Miller2, and D.J. Maitland1
1Dept. Biomedical Engineering, TX A&M University; 2Texas Institute for Preclinical Studies, TX A&M University, College Station, TX

56. Nanoparticle Delivery via Angioplasty Balloons for Treatment of Atherosclerosis
Roshni Iyer1,3, Serkan Yaman1,3, Aneetta E. Kuriakose1,3, Lee-Chun Su1, Hao Xu 2, Subhash Banerjee2, 3, Jian Yang4 , Kytai T. Nguyen1,3
1University of TX at Arlington, Arlington TX; 2VA North TX Health Care System at Dallas, Dallas TX; 3 University of TX Southwestern Medical Center at Dallas, Dallas TX; 4Pennsylvania State University, State College PA

57. Long-Term Safety and Stability of Carbon Nanotube Fiber as Active Interfaces with Excitable Tissues
Jiaxi Stephen Yan1,2, Flavia Vitale2, and Matteo Pasquali2,3
1Department of Bioengineering, Rice University; 2Department of Chemical and Biomolecular Engineering, Rice University; 3Department of Chemistry, Department of Material Science & NanoEngineering, The Smalley Institute for Nanoscale Science & Technology, Rice University, Houston, TX 

58. Antifouling Silicones Prepared with PEO-Silane Amphiphiles
Melissa L. Hawkins1, Samantha M. Schott1, Bagrat Grigoryan1, Marc A. Rufin1, Elizabeth S. Raymond2, Jeffery E. Raymond3, Melissa A. Grunlan1,4
Texas A&M University, 1Department of Biomedical Engineering, 2Department of Neuroscience and Experimental Therapeutics, 3Department of Chemistry, Laboratory for Synthetic-Biologic Interactions, 4Department of Materials Science and Engineering, College Station, TX

59. Peptide Stereochemistry as an Emerging Design Tool for Self-Assembling Biomaterials
Alexey Y. Koyfman1, Rajagopal Appavu1, Samantha M. Sheller2, Joshua D. Snook1, Mark A. White2, and Jai S. Rudra1
1Department of Pharmacology and Toxicology, 2Department of Biochemistry and Molecular Biology, University of Texas Medical Branch, Galveston, TX

60. Engineered RNA Nanorings for Efficient Delivery of siRNA
Alexey Koyfman1, Kirill Afonin2, Angelica Martins2, Eric Freed2, Wah Chiu3, Jai Rudra1, and Bruce Shapiro2
1Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston TX; 2National Cancer Institute, Frederick, MD; 3Department of Biochemistry and Molecular Biology, Baylor College of Medicine, Houston, TX

61. Mimicking the Human Trabecular Bone Niche for Bone Augmentation and Spinal Fusion
Silvia Minardi1,2, Bruna Corradetti1, Francesca Taraballi1, Fernando J. Cabrera1, Jeffrey Van Eps1, Anna Tampieri2, Bradley K. Weiner1, Ennio Tasciotti1
1Center for Regenerative Medicine, Houston Methodist Research Institute, Houston, TX; 2 Department of Life and Environmental Sciences, Universita’ Politecnica delle Marche, Ancona, Italy

62. Solvent-free Fabrication of Polyhipe Microspheres for Controlled Release of Growth Factors
Michael Whitely; Robert Moglia; Megan Brooks; Jennifer Robinson; Michael Pishko and Elizabeth Cosgriff-Hernandez*
*Texas A&M University, College Station, TX

63. Degradation of Thermoset Shape Memory Polyurethanes and Foams
Andrew C Weems, Duncan J Maitland
Dept. Biomedical Engineering, Texas A&M University, College Station, USA